Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
نویسندگان
چکیده
AIM OF THE STUDY To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro. MATERIAL AND METHODS The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis. RESULTS Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King's formula). CONCLUSIONS Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
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